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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe EULAR response criteria for polymyalgia rheumatica (PMR) and the PMR-disease activity score (PMR-AS) were developed to measure improvement after treatment with corticosteroid therapy. A diagnosis of PMR is based on the amount of pain and stiffness in the shoulder and pelvic girdle, muscle tenderness in the upper and lower limbs, non-specific somatic complaints, frequently occurring fever, weight loss, and fatigue.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Einflammatory disorders clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/6\/3\/12\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1505554333\u0022 data-figure-caption=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure1\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/6\/3\/12\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/6\/3\/12\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/6\/3\/12\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/10849\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-2\u0022\u003EThe EULAR response criteria for polymyalgia rheumatica (PMR) and the PMR-disease activity score (PMR-AS) were developed to measure improvement after treatment with corticosteroid therapy. A diagnosis of PMR is based on the amount of pain and stiffness in the shoulder and pelvic girdle, muscle tenderness in the upper and lower limbs, non-specific somatic complaints, frequently occurring fever, weight loss, and fatigue. The EULAR response criteria includes the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, VAS pain score, Physician\u0027s Global assessment, morning stiffness (MST), and the ability of the patient to elevate the upper limbs (\u003Cem\u003EAnn Rheum Dis\u003C\/em\u003E 2004;63:1279\u201383).\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EAlthough corticosteroid treatment has been shown to result in rapid and dramatic improvement and a return to previous functional status (\u003Cem\u003EArch Intern Med\u003C\/em\u003E 1999;22:577\u201384), long term use is associated with significant adverse events. In this diagnostic criteria validation study the initial mean dose of corticosteroids was tapered from 24.68 mg prednisolone equivalent to 7.68 mg or from 27.35 mg to 4.23 mg at week 24. Along with the reduction of corticosteroids, almost all parameters of disease activity showed significant improvement indicating decrease of inflammatory activity, reduction of pain, and amelioration of functional status of the patients (\u003Cem\u003EAnn Rheum Dis\u003C\/em\u003E 2003;62:1189\u201394). Internal consistency for the PMR-AS scoring system was high as indicated by the Cronbach\u0027s alpha composite scores of 0.914 and 0.881, while each single item contributed significantly to the total score.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe PMR-AS can be calculated as CRP (mg\/dl) + VAS p (0\u201310) + VAS ph (0\u201310) + [MST (min)* 0.1] + EUL (3\u20130). PMR-AS values below 7 indicated low disease activity, 7 to 17 medium activity, and \u0026gt;17 high activity. Further, the PMR-AS was proven to be highly correlated to the patient\u0027s global assessment, patient satisfaction and ESR (p\u0026lt;0.001) (\u003Cem\u003EAnn Rheum Dis\u003C\/em\u003E 2004;63:1279\u201383). Remission can be defined PMR-AS \u0026lt;2 and a VAS score of \u0026lt;10, regardless of the therapeutic intervention.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EIt is anticipated that monitoring disease activity, as well as increased risk-estimation of treatment schedules, e.g. corticosteroids, will improve clinical decision-making and care for PMR patients.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2006 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/6\/3\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzlyfe\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzlyfe\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}