<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors></authors><secondary-authors><author><style face="normal" font="default" size="100%">Zile, Michael</style></author><author><style face="normal" font="default" size="100%">Levy, Dan</style></author><author><style face="normal" font="default" size="100%">Pfeffer, Marc A.</style></author><author><style face="normal" font="default" size="100%">Greenberg, Barry</style></author><author><style face="normal" font="default" size="100%">Carabello, Blase</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Progression from Hypertension to Heart Failure: Mechanisms, Epidemiology, and Prevention</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-04-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">27-27</style></pages><abstract><style  face="normal" font="default" size="100%">Michael Zile, MD, Medical University of South Carolina, discussed the HTN-HF continuum, focusing on matrix mettalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Research conducted at his own institution measured plasma profiles of MMPs and TIMPs in HF patients and age-matched healthy people. “We know that inflammatory cytokines induce MMP expression in vitro,” Dr. Zile said. The South Carolina investigators detected MMP/TIMP ratios elevated as high as 16-fold in hypertensive patients with HF.</style></abstract><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">6</style></volume></record></records></xml>