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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n\n\u003Cp id=\u0022p-1\u0022\u003EDear Colleagues,\u003C\/p\u003E\n\u003Cp id=\u0022p-2\u0022\u003EWe are delighted to share with you the official peer-reviewed highlights from ACC.15, the 64th Annual Scientific Session of the American College of Cardiology, held March 14 to 16, 2015, in San Diego. The articles in this edition of \u003Cem\u003EMD Conference Express\u00ae\u003C\/em\u003E represent the most noteworthy, cutting-edge topics for a broad array of practitioners.\u003C\/p\u003E\n\u003Cp id=\u0022p-3\u0022\u003ESeveral studies covered in this edition will influence clinical practice today and others to follow in the near future. A benefit with prolonged dual antiplatelet therapy (DAPT) was determined for the first time in stable patients on average 2 years after a prior myocardial infarction (MI). The PEGASUS-TIMI 54 trial showed a reduction in the composite of cardiovascular (CV) death, MI, or stroke with ticagrelor vs placebo on top of aspirin, whereas TIMI major bleeding was increased. A new analysis from the DAPT study found a reduction in risk of stent thrombosis with prolonged DAPT in patients with or without acute coronary syndromes when undergoing coronary stenting and who were randomized 1 year later. Catheter ablation (when compared to amiodarone) increased freedom from atrial fibrillation (AF) and reduced hospitalization and mortality in patients with AF and heart failure in the AATAC study. The 5-year results of PARTNER 1 showed that transcatheter aortic valve replacement provides a durable alternative in patients who are at high risk for surgical replacement. Finally, potent low-density lipoprotein cholesterol (LDL-C) reduction with a novel PCSK9 inhibitor reduced CV outcomes in the OSLER extension studies. Evolocumab reduced LDL-C by 61% and the composite outcome of death, coronary and cerebrovascular events, and heart failure hospitalization by 53%. Definitive confirmation of these findings is awaited from an ongoing phase 3 outcomes trial.\u003C\/p\u003E\n\u003Cp id=\u0022p-4\u0022\u003EWe hope that you will find the articles and practical perspectives contained in the pages of this edition of \u003Cem\u003EMD Conference Express\u003C\/em\u003E to be useful in your clinical practice. For more information, please visit \u003Ca href=\u0022http:\/\/www.mdconferencexpress.com\u0022\u003Ewww.mdconferencexpress.com\u003C\/a\u003E.\u003C\/p\u003E\n\u003C\/div\u003E\u003Cdiv class=\u0022sig-block\u0022\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003ERobert P. Giugliano, MD, SM\u003C\/strong\u003E\u003Cbr\/\u003EEditor-in-Chief,\u003Cbr\/\u003E\u003Cem\u003EMD Conference Express\u003C\/em\u003E\u003Cbr\/\u003ECardiovascular Division\u003Cbr\/\u003EBrigham and Women\u2019s Hospital\u003Cbr\/\u003EAssociate Professor of Medicine\u003Cbr\/\u003EHarvard Medical School\u003Cbr\/\u003EBoston, Massachusetts\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003ENihar R. Desai, MD, MPH\u003C\/strong\u003E\u003Cbr\/\u003EAssociate Physician\u003Cbr\/\u003ECardiovascular Division\u003Cbr\/\u003EYale-New Haven Hospital\u003Cbr\/\u003ENew Haven, Connecticut\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003EDylan L. Steen, MD, MS\u003C\/strong\u003E\u003Cbr\/\u003EAssistant Professor\u003Cbr\/\u003ECardiovascular Division\u003Cbr\/\u003EUniversity of Cincinnati\u003Cbr\/\u003ECincinnati, Ohio\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003EMarc P. Bonaca, MD, MPH\u003C\/strong\u003E\u003Cbr\/\u003EAssociate Physician\u003Cbr\/\u003ECardiovascular Division\u003Cbr\/\u003EBrigham and Women\u2019s Hospital\u003Cbr\/\u003EInstructor in Medicine\u003Cbr\/\u003EHarvard Medical School\u003Cbr\/\u003EBoston, Massachusetts\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003EMatthew Cavender, MD, MPH\u003C\/strong\u003E\u003Cbr\/\u003EInterventional Cardiology, Heart, and Vascular Center\u003Cbr\/\u003EBrigham and Women\u2019s Hospital\u003Cbr\/\u003EBoston, Massachusetts\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003ESameer Bansilal, MD, MS\u003C\/strong\u003E\u003Cbr\/\u003EAssistant Professor\u003Cbr\/\u003EMount Sinai Heart Hospital\u003Cbr\/\u003EIcahn School of Medicine at Mount Sinai\u003Cbr\/\u003ENew York, New York\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003EJacob A. Udell, MD, MPH\u003C\/strong\u003E\u003Cbr\/\u003EAssociate Physician\u003Cbr\/\u003ECardiovascular Division\u003Cbr\/\u003EWomen\u2019s College Hospital\u003Cbr\/\u003EAssistant Professor of Medicine\u003Cbr\/\u003EUniversity of Toronto\u003Cbr\/\u003EToronto, Ontario, Canada\u003C\/p\u003E\u003C\/div\u003E\n\u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\u003Cstrong\u003EErin A. Bohula May, MD, PhD\u003C\/strong\u003E\u003Cbr\/\u003EAssociate Physician\u003Cbr\/\u003ECardiovascular Division\u003Cbr\/\u003EBrigham and Women\u2019s Hospital\u003Cbr\/\u003EInstructor in Medicine\u003Cbr\/\u003EHarvard Medical School\u003Cbr\/\u003EBoston, Massachusetts\u003C\/p\u003E\u003C\/div\u003E\n\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzlope\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}