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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ETreatment with levodopa-carbidopa intestinal gel leads to reduction in nonmotor symptoms in patients with advanced Parkinson\u2019s disease, with significantly lower Non-Motor Symptoms Scale total scores and scores for the individual domains of sleep\/fatigue, sexual function, and miscellaneous. Safety results are similar to those seen in prior studies with levodopa-carbidopa intestinal gel.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Elevodopa-carbidopa intestinal gel\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EParkinson\u2019s disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Enonmotor symptoms\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENCT01736176\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eneurology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EInterim data from an ongoing phase 3b trial, presented in a poster by Jordan Dubow, MD, AbbVie, Inc., North Chicago, Illinois, USA, indicated that treatment with levodopa-carbidopa intestinal gel (LCIG) significantly improved nonmotor symptoms (NMSs) in patients with advanced Parkinson disease (PD).\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003ENMSs play an important role, clearly affecting health-related quality of life (HRQOL) of patients with PD. LCIG (carbidopa-levodopa enteral suspension) is an effective treatment option for motor fluctuations in advanced refractory PD [Olanow CW et al. \u003Cem\u003ELancet Neurol\u003C\/em\u003E. 2014]. Open-label studies have shown that LCIG is associated with significant improvements in NMSs and HRQOL in patients with advanced PD [Fasano A et al. \u003Cem\u003EEur Rev Med Pharmacol Sci\u003C\/em\u003E. 2012; Reddy P et al. \u003Cem\u003EClin Neuropharmacol\u003C\/em\u003E. 2012].\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThis phase 3b, open-label, multicenter study [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01736176\u0026amp;atom=%2Fspmdc%2F15%2F9%2F11.2.atom\u0022\u003ENCT01736176\u003C\/a\u003E] included patients aged \u2265\u200530 years with levodopa-responsive idiopathic PD and severe motor fluctuations with \u2265\u20053 hours of \u201coff\u201d time\/day (despite individually optimized therapy). After conversion to oral levodopa-carbidopa, all patients underwent a percutaneous endoscopic gastrostomy-jejunostomy placement procedure. The study included an initial 12-week LCIG treatment period and a 48-week long-term treatment period. The primary end point was the change in NMSs from baseline to week 12 as measured by the Non-Motor Symptoms Scale (NMSS) total score. Secondary end points included the change from baseline to week 12 in the 9 NMSS domains. Adverse events (AEs) were recorded. Interim analysis was completed for the first 17 of 36 participants.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EPatients had a mean age of 64 years (range, 45-76), 65% were men, and 94% were white. Mean exposure to LCIG was 180 days (range, 5-368 days). Fourteen of 17 patients had a reduction in NMSS total score between baseline and final evaluation; the mean reduction was 38.3% (\u201320.7; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.001).\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003ESignificant decreases were noted in 3 of the 9 NMSS domains: sleep\/fatigue (\u20136.7; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.008), sexual function (\u20132.5; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.011), and miscellaneous (\u20134.9; \u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.002).\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EAt least 1 treatment-emergent AE was reported for 16 patients, and 2 patients discontinued due to AEs. The most frequently reported AEs were procedural pain (65%) and anxiety (24%). Serious AEs were reported for 2 patients; neither was considered related to LCIG.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThis study provides additional evidence that LCIG can be a safe and effective treatment for NMSs in patients with advanced PD.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/15\/9\/11.2.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzlo0d\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}