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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EALTER0302, a randomized double-blind controlled phase 2 trial, examined the efficacy and safety of anlotinib, a multitargeted tyrosine kinase inhibitor, as third-line therapy for Chinese patients with advanced non\u2013small cell lung cancer. Progression-free survival and objective response rates were increased in all subgroups of patients treated with anlotinib with no associated serious adverse events.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Enon\u2013small cell lung cancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Erefractory advanced non\u2013small cell lung cancer\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eanlotinib\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eprogression-free survival\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ENCT01924195\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EALTER0302\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ethird-line chemotherapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eoncology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003ELung cancer, approximately 85% of which is non\u2013small cell lung cancer (NSCLC), is the leading cause of cancer-related mortality worldwide, with an overall 5-year survival rate of 14% for stage IIIA and 1% for stage IV [American Cancer Society. \u003Ca href=\u0022http:\/\/www.cancer.org\/cancer\/lungcancer-non-smallcell\/detailedguide\/non-small-cell-lung-cancer-survival-rates\u0022\u003Ehttp:\/\/www.cancer.org\/cancer\/lungcancer-non-smallcell\/detailedguide\/non-small-cell-lung-cancer-survival-rates\u003C\/a\u003E. Accessed April 22, 2015]. In the past 30 years, mortality from lung cancer in China has increased by 465%, and lung cancer has been the main cause of death in urban populations [She J et al. \u003Cem\u003EChest\u003C\/em\u003E. 2013; Wen C, Dehnel T. \u003Cem\u003ELancet Oncol\u003C\/em\u003E. 2011].\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EBaohui Han, MD, PhD, Shanghai Chest Hospital, Shanghai, China, and colleagues examined the efficacy and safety of anlotinib\u2014a multitargeted tyrosine kinase inhibitor, with targets that include vascular endothelial growth factor receptors 2 and 3\u2014as third-line therapy for refractory advanced NSCLC in the randomized double-blind placebo-controlled phase 2 trial ALTER0302 [Han B et al. \u003Cem\u003EAnn Oncol.\u003C\/em\u003E 2015]. The primary end point for this study was progression-free survival (PFS), while the secondary end points included objective response rate (ORR), overall survival, and safety.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EProf Han and colleagues enrolled 117 patients (aged\u2005\u2265\u200518 years) from 13 hospitals in China with histologically confirmed metastatic advanced NSCLC who had progressed after first- and second-line chemotherapy; had adequate hematologic, renal, and liver function; and had an ECOG PS of 0 or 1. Patients with small cell lung cancer or those with a history of hemoptysis or symptomatic brain metastases were excluded. Patients were randomized 1:1 to either anlotinib (n\u2005=\u200560; 12 mg\/d, orally, day 1\u201314 every 3 weeks) or placebo (n\u2005=\u200557; 0 mg\/d, orally, day 1\u201314 every 3 weeks) until disease progression, unacceptable toxicity, withdrawal of patient consent, or death.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EBaseline characteristics of patients stratified by age, sex, smoking history, ECOG PS, histology, stage, and number of metastases were comparable between patients receiving anlotinib and placebo. The majority of the patients had adenocarcinoma with an ECOG PS of 1, stage IV NSCLC, and \u0026gt;\u20053 metastatic lesions. Prof Han reported that PFS, the primary end point of this study, was significantly increased from 1.23 months in the placebo arm to 4.83 months in the anlotinib arm (log-rank \u003Cem\u003EP\u003C\/em\u003E\u2005\u0026lt;\u2005.0001; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). This survival benefit was observed in all patient-stratified subgroups.\u003C\/p\u003E\n         \u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/8\/16.1\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Comparison of PFS: Anlotinib vs Placebo Treatment ArmsPFS, progression-free survival.Reproduced with permission from B Han, MD, PhD.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-664180475\u0022 data-figure-caption=\u0022Comparison of PFS: Anlotinib vs Placebo Treatment ArmsPFS, progression-free survival.Reproduced with permission from B Han, MD, PhD.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/8\/16.1\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/8\/16.1\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/15\/8\/16.1\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16308\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EComparison of PFS: Anlotinib vs Placebo Treatment Arms\u003C\/p\u003E\n               \u003Cp id=\u0022p-7\u0022\u003EPFS, progression-free survival.\u003C\/p\u003E\n               \u003Cp id=\u0022p-8\u0022\u003EReproduced with permission from B Han, MD, PhD.\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-9\u0022\u003EAlthough overall survival data have yet to accrue, secondary end points of this study, including ORR, extended the observed beneficial effects seen with anlotinib. Patients in the anlotinib arm exhibited a 10.00% ORR compared with 0% in the placebo arm (\u003Cem\u003EP\u003C\/em\u003E\u2005\u0026lt;\u2005.027), and the disease control rate was reported in 83.33% of anlotinib-treated patients vs 31.58% in those treated with placebo (\u003Cem\u003EP\u003C\/em\u003E\u2005\u0026lt;\u2005.0001). Although no serious adverse events (AEs) were noted in this study, AEs were increased from 70.2% in patients receiving placebo to 91.7% in those receiving anlotinib (\u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.004). Grade 3 and 4 AEs were 15.8% in the placebo arm and 26.7% in the anlotinib arm (\u003Cem\u003EP\u003C\/em\u003E\u2005=\u2005.1797) and included hypertension, hand-foot syndrome, and thyroglobulin. Based on the results of this clinical trial, Prof Han and colleagues concluded that anlotinib has significant PFS benefit as a third-line therapy in this selected Chinese population of patients with refractory advanced NSCLC with no associated serious AEs.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2015 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/15\/8\/16.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzlni2\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzlni2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}