PT - JOURNAL ARTICLE AU - Rizzo, Toni ED - Horwitz, Mara J. ED - Brown, Jacques P. ED - McClung, Michael R. TI - Novel Approaches to the Treatment of Osteoporosis DP - 2015 Jun 18 TA - MD Conference Express PG - 19--22 VI - 15 IP - 4 4099 - http://mdc.sagepub.com/content/15/4/19.short 4100 - http://mdc.sagepub.com/content/15/4/19.full AB - The 2 currently available categories of osteoporosis therapies are the antiresorptive agents, which decrease bone resorption and bone formation, and parathyroid hormone agonists, which increase bone formation and bone resorption. Cathepsin K inhibition is a new mechanism of action that inhibits bone resorption while preserving bone formation.