Effect of FimH Antagonist on Escherichia coli Concentration in Mice

CFU, colony forming units; CIP, ciprofloxacin; PO, orally; SC, subcutaneous.

Adapted with permission from Kleeb S et al, FimH Antagonists: Bioisosteres to Improve the in Vitro and in Vivo PK/PD Profile, J Med Chem, 2015, Vol 58, Pages 2221-2239. Copyright 2015 American Chemical Society.