RT Journal Article
SR Electronic
A1 Shuman, Jill
T1 New Antibiotic Combination for Treating Complicated Intra-abdominal Infections
JF MD Conference Express
YR 2015
FD SAGE Publications
VO 15
IS 48
SP 14
OP 16
DO 10.1177/1559897715591769
UL http://mdc.sagepub.com/content/15/48/14.abstract
AB Pooled data from RECLAIM 1 and 2 found that a new combination of antibiotics, incorporating ceftazidime plus avibactam plus metronidazole, was noninferior to meropenem in patients with complicated intra-abdominal infections, with no known safety signals. At the dose studied, the combination was less effective than meropenem to patients with renal impairment at baseline; however, new dosing recommendations are likely to remediate this.