PT  - JOURNAL ARTICLE
AU  - Shuman, Jill
ED  - Mazuski, John E.
TI  - New Antibiotic Combination for Treating Complicated Intra-abdominal Infections
DP  - 2015 Jul 23
TA  - MD Conference Express
PG  - 14--16
VI  - 15
IP  - 48
4099  - http://mdc.sagepub.com/content/15/48/14.short
4100  - http://mdc.sagepub.com/content/15/48/14.full
AB  - Pooled data from RECLAIM 1 and 2 found that a new combination of antibiotics, incorporating ceftazidime plus avibactam plus metronidazole, was noninferior to meropenem in patients with complicated intra-abdominal infections, with no known safety signals. At the dose studied, the combination was less effective than meropenem to patients with renal impairment at baseline; however, new dosing recommendations are likely to remediate this.