PT  - JOURNAL ARTICLE
AU  - Zarifyan, Alla
ED  - Nattel, Stanley
ED  - Verma, Atul
ED  - Berenfeld, Omer
ED  - Haïssaguerre, Michel
TI  - Persistent Atrial Fibrillation
DP  - 2015 Aug 02
TA  - MD Conference Express
PG  - 22--23
VI  - 15
IP  - 12
4099  - http://mdc.sagepub.com/content/15/12/22.short
4100  - http://mdc.sagepub.com/content/15/12/22.full
AB  - Atrial fibrillation can become self-sustaining due to structural remodeling that results in changes in ion currents over time. Treatment of atrial fibrillation with ablation does not appear to be improved by additional substrate ablation (CFE or Lines) when performed in addition to PVI. There is also mounting evidence for the role of rotors in AF. Many patients experience termination of atrial fibrillation following ablation of rotor sites, suggesting that therapies that target rotors may be one approach to reduce the burden of AF.