Figure 2. Histopathological Progression and Risk Factors of ALD
Spectrum of ALD, risk factors, and comorbidity. More than 95% of heavy drinkers develop fatty liver, but only up to 35% of this population develops more severe forms of ALD, including fibrosis, alcoholic hepatitis, cirrhosis, and HCC. Many risk factors have been proposed for the severe forms of ALD. Alcohol consumption and comorbid factors act in synergy to accelerate the progression of ALD.
Reprinted from Gastroenterology, Vol. 141, Gao B et al, Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets, Pages No. 1572-1585, Copyright (2011), with permission from AGA Institute.