PT - JOURNAL ARTICLE AU - Shuman, Jill ED - Sarode, Ravi ED - Dzik, Sunny TI - Treating Anticoagulant-Associated Bleeding DP - 2015 Sep 10 TA - MD Conference Express PG - 26--27 VI - 15 IP - 21 4099 - http://mdc.sagepub.com/content/15/21/26.short 4100 - http://mdc.sagepub.com/content/15/21/26.full AB - Agents that reverse the effect of vitamin K antagonists include plasma, vitamin K, and prothrombin complex concentrate. Hemostasis is most likely to be achieved by using a prothrombin complex concentrate. Guidelines for reversing the effect of direct-acting anticoagulants are based on guidelines that reflect the paucity of high-quality evidence.