Effect of 4F-PCC vs Placebo on Bleeding Time

Effect of treatment with 4F-PCC or placebo on the mean ratio of post–4F-PCC infusion to baseline from bleeding duration (minutes) (A), baseline bleeding volume (mL) (B), ETP (nM×min) (C), and for mean percent change in PT (seconds) (D). Error bars represent upper limit of the 95% CI.

CI indicates confidence interval; ETP, endogenous thrombin potential; 4F-PCC, 4-factor prothrombin complex concentrate; and PT, prothrombin time.

Reprinted from Zahir H et al., Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate, Circulation. 2015, Volume 131, Issue 1, Pages 82–90, with permission from American Heart Association, Inc.