PT - JOURNAL ARTICLE AU - Shuman, Jill ED - Roberts, Ian ED - Mann, Kenneth TI - Management of Posttraumatic Bleeding and Trauma-Induced Coagulopathy DP - 2015 Sep 10 TA - MD Conference Express PG - 22--23 VI - 15 IP - 21 4099 - http://mdc.sagepub.com/content/15/21/22.short 4100 - http://mdc.sagepub.com/content/15/21/22.full AB - Data from the CRASH-2 trial showed that tranexamic acid significantly reduced mortality in trauma patients, but no harm was detected. It is most effective when tranexamic acid is administered within 3 hours of the initial traumatic event. The TACTIC collaboration is currently conducting multiple preclinical and clinical studies to better manage posttraumatic hemorrhage.