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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents a summary of essential tremor and treatment options, an overview of Parkinson\u0027s disease, as well as discusses the latest genetic classification and treatment information for patients with dystonia.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EExtrapyramidal \u0026amp; Movement Disorders\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EExtrapyramidal \u0026amp; Movement Disorders\u003C\/li\u003E\u003C\/ul\u003E\u003Cblockquote id=\u0022disp-quote-1\u0022 class=\u0022disp-quote\u0022\u003E\n         \u003Cp id=\u0022p-2\u0022\u003EI. Classic essential tremor (ET) is a heterogeneous tremor syndrome without signs of other neurological impairment. The prevalence and the incidence of ET increase with age, with \u22655% of people aged \u0026gt;65 years estimated to have ET. Roger Elble, MD, PhD, Southern Illinois University School of Medicine, Springfield, Illinois USA presented a summary of ET and treatment options.\u003C\/p\u003E\n      \u003C\/blockquote\u003E\u003Cp id=\u0022p-3\u0022\u003EET can be difficult to diagnose so information from a careful neurologic examination and drug history must be obtained to distinguish ET from other disorders such as dystonia and early Parkinson\u0027s disease [Schiebler S et al. \u003Cem\u003EMov Disord\u003C\/em\u003E 2011; Deuschl G et al. \u003Cem\u003EMov Disord\u003C\/em\u003E 1998]. Electrophysiologic testing can help differentiate ET from physiologic tremor, orthostatic tremor, cortical tremor, and psychogenic tremor. Dopamine transporter single-photon emission computed tomography is useful in distinguishing ET and dystonic tremor from early Parkinson\u0027s disease. Dr. Elble emphasized that anxiety and depression in patients with ET are common and should not be overlooked, because they often have a greater negative effect on quality of life than the tremor itself.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPharmacotherapy for ET is limited and often inadequate. Primidone and propranolol remain the 2 most efficacious drugs for ET, with \u223c50% of patients responding to either drug. The responses can be dramatic but are typically not sustained, with efficacy diminishing over time. Some success has been obtained with topiramate treatment, but its use may be accompanied by cognitive impairment. Other agents such as zonisamide, levetiracetam, gabapentin, pregabalin, amantadine, benzodiazepines, methazolamide, flunarizine, nimodipine, clonidine, low-dose theophylline, clozapine, mirtazapine, 3,4-diaminopyridine, lacosamide, memantine, and carisbamate have been tested, but the results have been either inconclusive or negative.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EVentrolateral thalamic and subthalamic deep brain stimulation (DBS) is an effective option for patients with disabling tremor who have not responded to drug therapy. However, risks associated with DBS therapy include hardware infections (\u0026lt;6%), migration or misplacement of leads (\u0026lt;5%), lead fractures (\u0026lt;5%), skin erosion (\u223c1%), symptomatic hemorrhage (\u223c2%), lack or loss of efficacy, and side effects of stimulation. Additionally, the benefit of DBS, as with pharmacotherapy, often diminishes over time, particularly in women. In 1 study of 45 patients, 33 (73.3%) reported a declining benefit after a mean of 18.8\u00b115 months (range, 3 to 75 months) [Shih LC et al. \u003Cem\u003EParkinsonism Relat Disord\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cblockquote id=\u0022disp-quote-2\u0022 class=\u0022disp-quote\u0022\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EII. Claire Henchcliffe, MD, DPhil, Weill Cornell Medical College, New York, New York, USA, gave an overview of Parkinson\u0027s disease (PD). An estimated 4.1 to 4.6 million patients are affected globally, with the number expected to more than double by 2030. The peak onset of PD is between the ages of 55 and 65 years. The hallmarks of PD include bradykinesia, rest tremor (in the majority), rigidity, and postural instability (later in the disease). These symptoms are usually asymmetric and respond to PD medications. Nonmotor symptoms such as constipation, hyposmia, mood changes, and rapid eye movement behavior disorder coincide with motor symptoms and are often apparent earlier in the progression of PD.\u003C\/p\u003E\n      \u003C\/blockquote\u003E\u003Cp id=\u0022p-7\u0022\u003EPD signs and symptoms may overlap with other neurodegenerative diseases, of ten leading to misdiagnosis. Biomarkers in development such as neuroimaging ligands and sophisticated biochemical and molecular techniques may lead to earlier and more accurate diagnoses of PD in the future.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EA variety of drugs are used in the treatment of PD (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E). Nonpharmacologic approaches include surgery, lifestyle management strategies, and complementary therapies. DBS of the subthalamic nucleus is the most frequently performed surgical procedure for PD in the United States. Optimal candidates for DBS are those who do not have significant cognitive decline or psychiatric comorbidities. Persistent benefit in bradykinesia, rigidity, tremor, and dyskinesias can be obtained, but the declines in gait and balance continue. Evidence suggests that exercise has possible neuroprotective effects and should be encouraged. Patients with PD often use complementary therapies such as diet, dietary and herbal supplements, vitamins, massage therapy, acupuncture, and traditional Chinese medicine.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/15911\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/15911\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15911\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-9\u0022 class=\u0022first-child\u0022\u003EMedications for Motor Symptoms of Parkinson\u0027s Disease\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cblockquote id=\u0022disp-quote-3\u0022 class=\u0022disp-quote\u0022\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EIII. The third movement disorder discussed was dystonia. Dystonia is characterized by sustained muscle contractions affecting one or more body parts, resulting in abnormal postures. Dystonia may occur intermittently or persistently, and the severity may vary over time. Nutan Sharma, MD, PhD, Massachusetts General Hospital, Boston, Massachusetts, USA, presented the latest genetic classification and treatment information for patients with dystonia. The number of genes associated with dystonia continues to grow rapidly, and current genetic information is summarized in \u003Ca id=\u0022xref-table-wrap-2-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T2\u0022\u003ETable 2\u003C\/a\u003E.\u003C\/p\u003E\n      \u003C\/blockquote\u003E\u003Cdiv id=\u0022T2\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/15913\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/15913\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15913\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 2.\u003C\/span\u003E \n            \u003Cp id=\u0022p-12\u0022 class=\u0022first-child\u0022\u003EMutations Associated with Dystonia\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-14\u0022\u003ESeveral approaches may be used to treat patients with dystonia. Physical therapy for dystonia can be helpful and may include orthopedic bracing devices. Pharmacotherapy includes the anticholinergic triheyphenidyl or the benzodiazepines clonazepam, diazepam, or lorazepam. The dopaminergic agents carbidopa\/levodopa should be administered to children with dystonia, but they have not been helpful in adult-onset dystonia. Tetrabenazine in daily doses of 50 to 100 mg may be helpful in tardive dystonia. In Dr. Sharma\u0027s experience, baclofen has been effective in treating cranial dystonias, but the sedating side effects outweigh any benefit in larger muscle dystonias.\u003C\/p\u003E\u003Cp id=\u0022p-15\u0022\u003EFour different chemodenervation agents are currently available in the United States: onabotulinumtoxinA, incobotulinumtoxinA, abobotulinumtoxinA, and rimabotulinumtoxinB. Dr. Sharma stressed that the units of these agents are not interchangeable. \u201cYou really need to know which brand you\u0027re using, and what brand the person has been treated with before,\u201d said Dr. Sharma. Many patients respond to these medications provided the appropriate dose is administered and the correct muscles are targeted. Excessive weakness is a frequent side effect, but the risk of developing antibodies is minimized if injections are given at intervals of \u0026gt;10 to 12 weeks.\u003C\/p\u003E\u003Cp id=\u0022p-16\u0022\u003EDBS is the surgical treatment of choice for dystonia patients who do not respond to medications or botulinumtoxin injections. The globus pallidus interna is the only approved site for DBS in dystonia. It takes at least 6 months to see maximal improvement, which is longer than the response time seen in patients with PD. In Dr. Sharma\u0027s experience, children with DYT1 have a dramatic response to DBS and continue to respond.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/6\/24.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzpac3\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzpac3\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}