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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EA novel Parachute implant system was found to improve the New York Heart Association (NYHA) class and 6-minute walk distance in patients with heart failure (HF). This article presents data from the Percutaneous Ventricular Restoration in Chronic Heart Failure Due to Ischemic Heart Disease trial.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHeart Failure\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHeart Failure\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EA novel Parachute implant system was found to improve the New York Heart Association (NYHA) class and 6-minute walk distance (6MWD) in patients with heart failure (HF). William T. Abraham, MD, Director of the Division of Cardiovascular Medicine, Ohio State University Wexner Medical Center, Columbus, Ohio, USA, presented data from the Percutaneous Ventricular Restoration in Chronic Heart Failure Due to Ischemic Heart Disease trial.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EHF results in at least 1 million hospitalizations per year, with 279,000 deaths and a 5-year mortality rate of about 50% [American Heart Association. \u003Cem\u003ECirculation\u003C\/em\u003E 2014]. After an anterior wall myocardial infarction (AWMI), eccentric wall motion during the AWMI causes left ventricular (LV) remodeling. Over time, the LV enlarges and wall tension rises, which impairs contractility of the myocardium. Therefore, an improvement in LV contraction is needed to resolve symptoms. The purpose of this study was to evaluate the safety and efficacy of the Parachute system in the treatment of HF after a remote MI.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe Parachute system is a collapsible, cuplike implant. Its dual-layer, occlusive membrane is made of polytetrafluoroethylene, which is supported at the edges with polypropylene sutures and a 16-arm frame. A urethane foot at the bottom of the Parachute implant functions as a shock absorber. The implant is delivered and anchored via a 20-cc balloon, which is guided by a catheter (available in 3 sizes). The Parachute implant decreases wall stress in the upper chamber of the heart by decreasing the volume of the LV. It also provides a trampoline effect, replacing scar tissue with a more compliant material that creates an outward force to enhance diastolic filing. Improved diastolic compliance reduces the end-diastolic filling pressure.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe first results from this trial are reported. The cohort comprised 111 consecutive, intent-to-treat patients with NYHA Class III to IV ischemic HF who had received a Parachute implant and were followed for 12 months. These patients were from the USA and Europe, were enrolled on or before December 31, 2012, and were treated for 1 year.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe mean age of the study population was 60.7 years and the mean body mass index was 28.5. Most patients were male (84%). Prior tobacco abuse (74%), hypertension (69%) and diabetes (35%) were common. The use of revascularization with either percutaneous coronary intervention (76%) or coronary artery bypass (17%) or the use of advanced heart failure therapies, such as implantable cardiac defibrillator (38%) or cardiac resynchronization therapy (18%), were also common.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe Parachute implant led to an improvement in NYHA class in 54% patients and maintained the class in 32% patients at the 1-year time point (\u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). In addition, patients with the Parachute implant experienced a significant improvement in their 6MWD (p\u0026lt;0.05).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/12\/23\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Effect of the Parachute Implant on NYHA Class\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-146140035\u0022 data-figure-caption=\u0022Effect of the Parachute Implant on NYHA Class\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/12\/23\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/12\/23\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/12\/23\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14356\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-8\u0022 class=\u0022first-child\u0022\u003EEffect of the Parachute Implant on NYHA Class\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003ENYHA=New York Heart Association.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003En=106 and refers to the number of patients discharged with the Parachute device.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003E*NYHA II at baseline had to be NYHA III or IV in the last 3 months.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-4\u0022\u003EReproduced with permission from WT Abraham, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-9\u0022\u003EThe 12-month stroke rate was 3%, the all-cause mortality was 6%, and the mortality plus HF hospitalization rate was 22%.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EDr. Abraham concluded that the Parachute implant could benefit some patients with congestive heart failure. The device is currently undergoing further evaluation in the PARACHUTE IV trial, which is now enrolling in the USA [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01614652\u0026amp;atom=%2Fspmdc%2F14%2F12%2F23.atom\u0022\u003ENCT01614652\u003C\/a\u003E].\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/12\/23.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzp5pe\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp5pe\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}