Summary

This article presents the results of a pooled analysis that addressed several questions concerning worsening heart failure (HF). The meta-analysis was based on patient-level data (n=3733) from 4 studies: the RELAX-AHF [Relaxin for the Treatment of Acute Heart Failure; Teerlink JR et al. Lancet 2013], the Pre-RELAX-AHF [Teerlink JR et al. Lancet 2009], the PROTECT pilot study [Pro-BNP Outpatient Tailored Chronic Heart Failure Therapy; Cotter G et al. J Cardiac Fail 2008], and PROTECT [Massie BM et al. N Engl J Med 2010].