PT - JOURNAL ARTICLE AU - Nichols, Emma Hitt ED - Packer, Milton TI - PARADIGM-HF: Rationale and Design DP - 2014 Aug 01 TA - MD Conference Express PG - 11--12 VI - 14 IP - 12 4099 - http://mdc.sagepub.com/content/14/12/11.short 4100 - http://mdc.sagepub.com/content/14/12/11.full AB - The Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure and Reduced Ejection Fraction [PARADIGM-HF; NCT01035255] is the largest trial ever conducted with patients with heart failure with a reduced left ventricular ejection fraction and was designed to replace the current standard of care. This article discusses the rationale and design of the PARADIGM-HF trial.