RT Journal Article SR Electronic A1 Hoyle, Brian T1 Advances in Prospective and Innovative Randomized Clinical Trials JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 14 SP 6 OP 8 DO 10.1177/155989771414002 UL http://mdc.sagepub.com/content/14/14/6.abstract AB Precision medicine uses traditional and emerging concepts of the genetic and environmental basis of disease to individualize prevention, diagnosis and treatment [National Cancer Institute, 2011]. It integrates the tumor genetics of individual patients into medical practice. The potential value of the targeted and precise approach is great. This article discusses advances in precision medicine from the perspective of prospective clinical trials. A specific example of melanoma as a model for personalized cancer medicine is also presented.