PT - JOURNAL ARTICLE AU - Hoyle, Brian ED - Eggermont, Alexander M. TI - Advances in Prospective and Innovative Randomized Clinical Trials DP - 2014 Aug 01 TA - MD Conference Express PG - 6--8 VI - 14 IP - 14 4099 - http://mdc.sagepub.com/content/14/14/6.short 4100 - http://mdc.sagepub.com/content/14/14/6.full AB - Precision medicine uses traditional and emerging concepts of the genetic and environmental basis of disease to individualize prevention, diagnosis and treatment [National Cancer Institute, 2011]. It integrates the tumor genetics of individual patients into medical practice. The potential value of the targeted and precise approach is great. This article discusses advances in precision medicine from the perspective of prospective clinical trials. A specific example of melanoma as a model for personalized cancer medicine is also presented.