RT Journal Article
SR Electronic
A1 Nichols, Emma Hitt
T1 Promises and Pitfalls of Gene Therapy in Parkinson's Disease
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 15
SP 27
OP 28
DO 10.1177/155989771415011
UL http://mdc.sagepub.com/content/14/15/27.abstract
AB Gene therapy was heralded as a potential cure for Parkinson's disease (PD) beginning in the 1990s. The idea was that by giving patients the genes they need, potentially their functionality could be restored. However, several initial clinical trials failed to provide positive results. These failures have provided lessons for the development of alternative potential gene therapies as well as other approaches, such as augmenting pharmacotherapy with gene therapy. Several new agents and techniques are currently in early-stage clinical trials.