RT Journal Article SR Electronic A1 Nichols, Emma Hitt T1 Understanding Parkinson's Pathology is Key to Early Detection and Treatment JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 15 SP 25 OP 26 DO 10.1177/155989771415010 UL http://mdc.sagepub.com/content/14/15/25.abstract AB Understanding the underlying pathology of Parkinson's disease (PD) is critical in identifying the disease early and developing novel treatments. This article discusses the role of a-synuclein in PD, the extranigral pathology and preclinical detection of PD, as well as how the updated understanding of PD pathology explains its clinical phenotype