RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 UPR Activation Evaluated in Lewy Body Dementias and AD
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 15
SP 13
OP 14
DO 10.1177/155989771415004
UL http://mdc.sagepub.com/content/14/15/13.abstract
AB Even though they have distinct clinical, pathologic, and biochemical features, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease, and less commonly prion disease are all characterized by misfolded protein aggregation in the brain and fatal neuronal loss. The unfolded protein response (UPR) is emerging as a common player in all neurodegenerative diseases. This article discusses a study that is investigating changes in the UPR pathway in deceased subjects with PD with dementia (PDD) and dementia with Lewy bodies in comparison with patients with AD and control subjects.