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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ELong-term disease control was observed with adalimumab administered in routine clinical practice to patients with moderately to severely active juvenile idiopathic arthritis (JIA). This article discusses interim findings from an analysis done at 4 years from an ongoing international registry of patients enrolled upon diagnosis of moderately to severely active JIA [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00783510\u0026amp;atom=%2Fspmdc%2F14%2F17%2F13.atom\u0022\u003ENCT00783510\u003C\/a\u003E].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EArthritis\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatological Autoimmune Disorders\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ELong-term disease control was observed with adalimumab administered in routine clinical practice to patients with moderately to severely active juvenile idiopathic arthritis (JIA), according to Gerd Horneff, MD, Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EInterim findings from an analysis done at 4 years were reported from an ongoing international registry of patients enrolled upon diagnosis of moderately to severely active JIA [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00783510\u0026amp;atom=%2Fspmdc%2F14%2F17%2F13.atom\u0022\u003ENCT00783510\u003C\/a\u003E]. The multicenter, noninterventional observational study aimed to evaluate long-term safety and effectiveness of adalimumab, which was recently approved for treating patients with severe and refractory JIA from the age of 2 years after failure or intolerance to methotrexate (MTX) treatment. Efficacy and safety were compared with MTX treatment administered in routine clinical practice. Patients aged 2 to 17 years were enrolled in the United States, European Union, and Australia. The planned follow-up was 10 years after enrollment in either treatment arm; crossover to the adalimumab group was allowed.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EPatients in the adalimumab cohort had a more advanced disease course compared with those of the MTX cohort. Baseline values for mean disease duration were 1.3 years in the MTX arm and 3.8 years in the adalimumab arm. Patients in the adalimumab arm had a mean age of 12.2 years, a mean weight of 47.8 kg, and a mean height of 150.3 cm compared with patients receiving MTX, who had a mean age of 9.6 years, a mean weight of 37.9 kg, and a mean height of 137.2 cm. Mean baseline active joint count in both groups was 5.8, and disability index of Childhood Health Assessment Questionnaire scores was 0.6 in each arm.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAt data cutoff, 306 patients received MTX monotherapy, and 459 received adalimumab with or without MTX. Clinical outcomes based on the 71-joint Juvenile Arthritis Disease Activity Score showed that mean scores improved from 13.1 at baseline to 11.2, 6.4, and 5.1 with MTX and from 12.1 at baseline to 8.5, 5.7, and 5.4 with adalimumab at Months 1, 3, and 6, respectively. In the MTX arm, 131 (42.8%) patients discontinued registry participation, compared with 81 (17.6%) in the adalimumab arm; 34 (25.9%) who discontinued MTX were switched to adalimumab.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EDiscontinuation due to treatment-related adverse events (AEs) occurred in 23 (7.5%) and 25 (5.4%) patients in the MTX and adalimumab cohorts, respectively. AEs determined by the investigators as possibly drug related were reported in 63 (20.6%) patients. Infectious AEs were reported for 64 (20.9%) and 80 (17.4%) of patients in the MTX and adalimumab arms, respectively. Of these, serious infectious AEs occurred in 7 (2.3%) MTX patients, compared with 12 (2.6%) adalimumab patients (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/14583\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/14583\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14583\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EOverview of Observational Adverse Events, n (%)\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-8\u0022\u003EIn the adalimumab arm, 12 (2.6%) patients had a serious infectious AE: acute tonsillitis, cellulitis, gastroenteritis, mononucleosis, viral meningitis, pneumonia, scarlet fever, subcutaneous abscess, tonsillitis, urinary tract infection, and varicella occurred in 1 patient each. No deaths, malignancies, tuberculosis, or opportunistic infections were reported with either treatment.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/17\/13.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp3e1\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzp3e1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}