PT - JOURNAL ARTICLE AU - Mosley, Mary ED - Metersky, Mark L. TI - Antibiotic Resistance: Treatment and Drug Development Challenges Addressed DP - 2014 Sep 01 TA - MD Conference Express PG - 28--29 VI - 14 IP - 11 4099 - http://mdc.sagepub.com/content/14/11/28.short 4100 - http://mdc.sagepub.com/content/14/11/28.full AB - The resistance of infectious organisms to currently available antibiotics is a major medical challenge. The prevalence and mechanisms of multidrug-resistant pathogens vary widely worldwide. In the United States and Europe, the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) appears to have stabilized, while it is increasing in other regions [Dantes R et al. JAMA Intern Med 2013]. Antibiotic resistance to gram-negative bacteria continues to increase and represents one of the biggest challenges.