Summary

Administration of acetaminophen to patients with severe sepsis and detectable plasma levels of cell-free hemoglobin (CFH) improved kidney function but did not appear to reduce oxidative injury. This article presents data from the Phase 2a randomized controlled trial of Acetaminophen for the Reduction of Oxidative Stress in Severe Sepsis trial [ACROSS; NCT01739361; Janz DR et al. Am J Respir Care Med 2014.]