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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article discusses results of the Effect of Rosuvastatin Treatment in Stable COPD study [RODEO; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00929734\u0026amp;atom=%2Fspmdc%2F14%2F11%2F19.atom\u0022\u003ENCT00929734\u003C\/a\u003E; Neukamm A et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2014], a randomized, double-blind clinical trial conducted to test the hypothesis that the use of statin therapy in patients with stable chronic obstructive pulmonary disease (COPD) would be associated with improved endothelial and pulmonary function and reduced systemic inflammation.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EPulmonary Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EChronic Obstructive Pulmonary Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EPulmonary \u0026amp; Critical Care\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPulmonary Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EChronic Obstructive Pulmonary Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe use of short-term rosuvastatin to treat patients with stable chronic obstructive pulmonary disease (COPD) reduces systemic inflammation but has no effect on pulmonary function and improves endothelial function only in patients with baseline C-reactive protein (CRP) levels \u0026gt;1.7 mg\/L.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EAnke Neukamm, MD, Cardiothoracic Research Group, Akershus University Hospital, Lorenskog, Norway, presented results of the Effect of Rosuvastatin Treatment in Stable COPD study [RODEO; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00929734\u0026amp;atom=%2Fspmdc%2F14%2F11%2F19.atom\u0022\u003ENCT00929734\u003C\/a\u003E; Neukamm A et al. \u003Cem\u003EAm J Respir Crit Care Med\u003C\/em\u003E 2014], a randomized, double-blind clinical trial conducted to test the hypothesis that the use of statin therapy in patients with stable COPD would be associated with improved endothelial and pulmonary function and reduced systemic inflammation.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe study included 99 patients with stable COPD who were randomly assigned to once-daily treatment with rosuvastatin 10 mg (n=49) or placebo (n=50) for 12 weeks. Patients were excluded from the study if they had histories of or active coronary artery diseases, other lung diseases except asthma bronchiale, uncontrolled arterial hypertension, histories of diabetes or hypercholesterolemia, or statin use within the 4 weeks prior to the onset of the study.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOf the 99 patients, 94 patients completed the study (47 in each treatment arm). Baseline characteristics were similar between the 2 groups for age (mean, 65 years), sex (48% women), history of hypertension (25%), and smoking habit (mean, 37 pack-years).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003ETo evaluate the effect of rosuvastatin on endothelial and pulmonary function and systemic inflammation, the primary endpoint was the change in peripheral vasodilator function measured by peripheral arterial tonometry and expressed as the reactive hyperemia ratio (RHI). The study also included a prespecified subgroup analysis of the effect of rosuvastatin in patients with elevated CRP levels.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003ESecondary endpoints included change in change in pulmonary function as assessed by forced expiratory volume in 1 second (FEV\u003Csub\u003E1\u003C\/sub\u003E) and the ratio of FEV\u003Csub\u003E1\u003C\/sub\u003E to forced volume capacity ratio (FVC), as well as change in the circulating proinflammatory markers CRP, interleukin-6 (IL 6), and high-sensitivity CRP (hsCRP).\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EIn an intention-to-treat analysis, the study found no difference between rosuvastatin and placebo in the primary end point of the study, vasodilator function.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EHowever, there was a significant difference in vasodilator function, as determined by the change in RHI, with rosuvastatin compared with placebo in the subgroup of patients with elevated baseline CRP levels (median \u0026gt;1.7 mg\/L, p=0.026).\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EIn terms of secondary endpoints, rosuvastatin was associated with a significant reduction in hsCRP and attenuated the rise in IL6 compared with placebo (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E). No significant differences were seen in pulmonary function in FEV\u003Csub\u003E1\u003C\/sub\u003E or FEV\u003Csub\u003E1\u003C\/sub\u003E\/FVC.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/14347\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/14347\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/14347\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-11\u0022 class=\u0022first-child\u0022\u003EResults of Secondary Endpoints\u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-18\u0022\u003EBased on these results, the investigators emphasize the need for long-term randomized trials with large cohorts to more accurately assess the benefits of statin therapy in patients with stable COPD.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/11\/19.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp203\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzp203\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}