RT Journal Article
SR Electronic
A1 Mosley, Mary
T1 Initial Combination Therapy Improves Hemodynamics and Function in Scleroderma PAH
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 11
SP 13
OP 13
DO 10.1177/155989771411006
UL http://mdc.sagepub.com/content/14/11/13.1.abstract
AB Patients with systemic sclerosis pulmonary arterial hypertension (SSc-PAH) have a worse prognosis than those with idiopathic PAH. Although the specific mechanisms are not known, it is thought to be related to persistent right ventricular dysfunction and pulmonary vascular remodeling despite guideline-directed management with a single agent for PAH. This article discusses a 36-week, open-label, multicenter observational study evaluating upfront therapy with 2 drugs, tadalafil and ambrisentan, that target distinct pathways in treatment-naïve patients with SSc-PAH [NCT01178073; Gashouta MA et al. Am J Respir Crit Care Med].