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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ECombination therapy of hypertension with perindopril and amlodipine resulted in a larger decrease in blood pressure (BP) compared with monotherapy with either agent or placebo. This article presents data from a clinical trial evaluating fixed-dose combination of perindopril and amlodipine in patients with hypertension.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHypertensive Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ECombination therapy of hypertension with perindopril and amlodipine resulted in a larger decrease in blood pressure (BP) compared with monotherapy with either agent or placebo. St\u00e9phane Laurent, MD, PhD, Hospital Europ\u00e9en Georges Pompidou, Paris, France, presented data from a clinical trial evaluating fixed-dose combination of perindopril and amlodipine in patients with hypertension.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EMany patients have uncontrolled hypertension even when taking combination therapy of current antihypertensive agents. Current treatment guidelines recommend the use of fixed combinations of antihypertensive therapies early in the disease course. The purpose of this trial was to evaluate a new generation of antihypertensive combination therapy with optimized doses for the first-line use in patients newly diagnosed with hypertension.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe primary end points included superiority of perindopril (3.5 mg) plus amlodipine (2.5 mg) compared with placebo and monotherapy and noninferiority of perindopril (3.5 mg) plus amlodipine (2.5 mg) compared with perindopril (5 mg) and amlodipine (5 mg). The secondary end points included the response rate and safety profile of combination therapy.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EIn the double-blind study, 1497 patients with hypertension were randomly assigned to receive perindopril monotherapy of 3.5 or 5 mg, amlodipine monotherapy of 2.5 or 5 mg, perindopril (3.5 mg) plus amlodipine (2.5 mg), or placebo for about 8 weeks. All patients received placebo during the 2- to 3-week run-in period. At baseline, the mean age was 51.7 years; 46.7% of patients were men; mean body mass index was 26.8 kg\/m\u003Csup\u003E2\u003C\/sup\u003E; mean weight was 77.7 kg; and mean abdominal waist circumference was 90.8 cm. In addition, 26.4% of patients were smokers; 26% consumed alcohol; 6.4% had hypercholesteremia; 5.9% had dyslipidemia; and 15% had metabolic syndrome.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe study met all the primary end points (p\u0026lt;0.001). Change in supine systolic BP from baseline was greatest in the perindopril + amlodipine arm (\u201322.0 mm Hg) and the amlodipine (5 mg) monotherapy arm (\u201321.8 mm Hg). The placebo (\u201314.2 mm Hg), perindopril (3.5 mg) monotherapy (\u201316.3 mm Hg), amlodipine (2.5 mg) monotherapy (\u201316.0 mm Hg), and perindopril (5 mg) monotherapy (\u201318.2 mm Hg) arms also showed a decrease in systolic BP from baseline. There was a similar trend for diastolic BP. In the combination therapy arm, 43.5% of patients experienced normalization, compared with 37.9%, 33.3%, and 26.6% in the amlodipine (5 mg), perindopril (5 mg), and placebo arms (p\u0026lt;0.001), respectively.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EA greater rate of lower limb edema was noted in patients who received amlodipine (5 mg) monotherapy compared with perindopril monotherapy or combination therapy. In contrast, cough and orthostatic hypotension occurred more frequently in the perindopril monotherapy arm compared with the amlodipine monotherapy and combination therapy arms.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EDr. Laurent stated that data from this trial indicate that perindopril (3.5 mg) + amlodipine (2.5 mg) combination therapy provides a better benefit-risk ratio compared with monotherapy, as the combination resulted in a greater reduction in BP with a similar safety profile. Therefore, he suggested that combination therapy of hypertension with perindopril (3.5 mg) plus amlodipine (2.5 mg) may be suitable as first-line therapy.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/18\/18.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzp1jd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}