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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EPrior 24-week Phase 3 clinical trials (randomized, double-blind) established the efficacy of empagliflozin (10 and 25 mg) in reducing systolic BP compared with placebo among patients with type 2 diabetes. This article presented findings of the 12 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Patients With Type 2 Diabetes Mellitus [EMPA-REG BP; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01370005\u0026amp;atom=%2Fspmdc%2F14%2F20%2F14.atom\u0022\u003ENCT01370005\u003C\/a\u003E], a placebo-controlled Phase 3 trial (randomized, double-blind).\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Ediabetes mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ehypertensive disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ediabetes \u0026amp; endocrinology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EEmpagliflozin, an investigational drug to treat type 2 diabetes that is being developed by Boehringer Ingelheim Pharma, lowered blood pressure (BP) in hypertensive type 2 diabetics and reduced blood glucose levels during 12 weeks of treatment. Afshin Salsali, MD, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA, presented findings of the 12 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Patients With Type 2 Diabetes Mellitus [EMPA-REG BP; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01370005\u0026amp;atom=%2Fspmdc%2F14%2F20%2F14.atom\u0022\u003ENCT01370005\u003C\/a\u003E], a placebo-controlled Phase 3 trial (randomized, double-blind).\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EPrior 24-week Phase 3 clinical trials (randomized, double-blind) established the efficacy of empagliflozin (10 and 25 mg) in reducing systolic BP compared with placebo among patients with type 2 diabetes [H\u00e4ring H-U et al. \u003Cem\u003EDiabetes Care\u003C\/em\u003E 2014; Kovacs CS et al. \u003Cem\u003EDiabetes Obes Metab\u003C\/em\u003E 2014; H\u00e4ring H-U et al. \u003Cem\u003EDiabetes Care\u003C\/em\u003E 2013; Roden M et al. \u003Cem\u003ELancet Diabetes Endocrinol\u003C\/em\u003E 2013]. The effect on blood sugar remained unclear.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe present study involved 823 subjects with type 2 diabetes and high BP (130\/80 to 159\/99 mm Hg) who were randomly assigned to receive placebo (n = 271), empagliflozin\u221210 mg (n = 276), and empagliflozin\u221225 mg (n = 276). The baseline demographics and clinical characteristics of the randomized patients were similar (\u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E).\u003C\/p\u003E\n         \u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/16431\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/16431\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/16431\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n               \u003Cp id=\u0022p-5\u0022 class=\u0022first-child\u0022\u003EBaseline and Clinical Characteristics of the 3 Patient Groups\u003C\/p\u003E\n            \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EAt baseline, the majority (63%) had an estimated glomerular filtration rate of 60 to 90 mL\/min\/1.73 m\u003Csup\u003E2\u003C\/sup\u003E. All patients wore an ambulatory BP cuff that monitored systolic and diastolic BP every hour for 24 hours at baseline (before treatment) and after 12 weeks of treatment. Blood samples were also acquired at baseline and 12 weeks to determine HbA\u003Csub\u003E1c\u003C\/sub\u003E levels as a measure of long-term blood sugar control.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EThe 24-hour pattern of systolic BP was almost identical for the 3 subject groups at baseline. At Week 12, while the 24-hour systolic BP curves for the 3 groups were similar in shape, the placebo group consistently displayed higher BP than either empagliflozin group. Empagliflozin\u221225 mg produced slightly lower 24-hour systolic BP than empagliflozin\u221210 mg.\u003C\/p\u003E\n         \u003Cp id=\u0022p-9\u0022\u003ESimilar results were found for diastolic BP. On average, systolic and diastolic BP among subjects who received the 25 mg of empagliflozin decreased by 4.2 mm Hg (p \u0026lt; .001) and 1.7 mm Hg (p \u0026lt; .01), respectively, compared with placebo. The average decrease in systolic and diastolic BP among patients who received the 10 mg of empagliflozin was 3.4 mm Hg (p \u0026lt; .001) and 1.4 mm Hg (p \u0026lt; .01), respectively, compared with placebo.\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EFrom baseline to Week 12, the average HbA\u003Csub\u003E1c\u003C\/sub\u003E level dropped by 0.62% and 0.65% with 10 and 25 mg of empagliflozin, respectively, compared with placebo. Subjects tolerated empagliflozin well, with no increased rate of side effects compared with placebo. Most adverse events that occurred in all 3 groups were mild.\u003C\/p\u003E\n         \u003Cp id=\u0022p-11\u0022\u003EThe authors speculate that the improved blood sugar levels evident in subjects receiving empagliflozin reflect reduced glucose reabsorption in the kidneys, which leads to glucose elimination in the urine. The findings suggest the potential of empagliflozin to reduce the risk of cardiovascular events with longer-term treatment. This possibility is being addressed in the long-term EMPA-REG OUTCOME trial [Zinman B et al. \u003Cem\u003ECardiovasc Diabetol\u003C\/em\u003E 2014], which is expected to finish in 2015. The primary end point of the latter trial is the time to first occurrence of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/20\/14.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzoyap\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzoyap\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}