RT Journal Article SR Electronic A1 Rizzo, Toni T1 Similar 12-Month BP Reductions with Renal Denervation and Sham Procedure JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 30 SP 21 OP 22 DO 10.1177/155989771430016 UL http://mdc.sagepub.com/content/14/30/21.abstract AB The Renal Denervation in Patients With Uncontrolled Hypertension trial [SYMPLICITY HTN-3; NCT01418261] was the first randomized, blinded, sham-controlled clinical trial of renal denervation for treatment-resistant hypertension. In addition to the blinding and sham control, post hoc analyses have identified potential factors that may account for the negative results, including the patient population and procedural variability, which are discussed in this 12-month post hoc analysis.