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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003ENew generation drug-eluting stents (DESs) are increasingly efficient and safe, while the ABSORB everolimus-eluting bioresorbable vascular scaffold (BVS) is thought to reduce long-term complications, including neoatherosclerosis and very late stent thrombosis. The objective of the Comparison of Everolimus- and Biolimus-Eluting Stents With Everolimus-Eluting Bioresorbable Vascular Scaffold Stent trial [EVERBIO II; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01711931\u0026amp;atom=%2Fspmdc%2F14%2F30%2F20.atom\u0022\u003ENCT01711931\u003C\/a\u003E] was to compare the efficacy of the BVS with the best-in-class new generation DESs.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003ENew generation drug-eluting stents (DESs) are increasingly efficient and safe. The ABSORB everolimus-eluting bioresorbable vascular scaffold (BVS) is thought to reduce long-term complications, including neoatherosclerosis and very late stent thrombosis. The effectiveness of the BVS has been demonstrated in patients with noncomplex lesions but it is increasingly being used in patients with complex lesions. The objective of the Comparison of Everolimus- and Biolimus-Eluting Stents With Everolimus-Eluting Bioresorbable Vascular Scaffold Stent trial [EVERBIO II; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01711931\u0026amp;atom=%2Fspmdc%2F14%2F30%2F20.atom\u0022\u003ENCT01711931\u003C\/a\u003E], presented by St\u00e9phane Cook, MD, University of Fribourg, Fribourg, Switzerland, was to compare the efficacy of the BVS with the best-in-class new generation DESs\u2014the everolimus-eluting stent (EES PROMUS ELEMENT) and biolimus-eluting stent (BES BIOMATRIX FLEX).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EPatients with stable coronary artery disease (CAD) or acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI) were randomized to the EES (n = 80), BES (n = 80), or BVS (n = 78). Clinical follow-up took place at 1, 6, 9, and 12 months and 2 and 5 years, with angiography at 9 months. The primary end point was in-stent late lumen loss (LLL) at 9 months. Secondary end points were in-segment LLL, patient-oriented major acute cardiac events (MACE; death, myocardial infarction [MI], and target vessel revascularization [TVR]), device-oriented MACE (cardiac death, MI, and target lesion revascularization), and stent thrombosis.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThere were no significant differences in baseline characteristics between the 3 groups. No significant difference was observed in the cumulative frequency of in-stent LLL between the EES and BES groups combined (EES\/BVS; 0.25 \u00b1 0.36 mm) and the BVS group (0.28 \u00b1 0.39 mm; \u003Cem\u003EP\u003C\/em\u003E = .30). At nine months, there was no significant difference in the cumulative frequency of in-stent LLL between the EES (0.24 \u00b1 0.32 mm), BES (0.25 \u00b1 0.41 mm), and BVS (0.28 \u00b1 0.39 mm) groups.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EStratified analysis found no significant differences in in-stent LLL between the EES\/BES and BVS groups in patients with or without diabetes, ACS, or complex lesions.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EIn-segment LLL was significantly more frequent with the BVS (0.30 \u00b1 0.44 mm) vs the EES\/BES (0.19 \u00b1 0.42 mm; \u003Cem\u003EP\u003C\/em\u003E = .03). Stratified analysis found no significant differences in in-segment LLL between the EES\/BES and BVS groups in patients with or without diabetes, ACS, or complex lesions.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThere were no significant differences in dual antiplatelet therapy (DAPT) use in the EES\/BES vs BVS, EES vs BVS, and BES vs BVS groups. No significant differences were observed in clinical outcomes at 9 months, including device-oriented MACE, patient-oriented MACE, TVR, and stent thrombosis, in the EES\/BES vs BVS, EES vs BVS, and BES vs BVS groups.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThis study had several limitations. It was not powered for noninferiority or to detect differences in clinical event rates. The study was performed in a single center with uniform procedural strategies that limit generalizations to other centers. Additionally, the investigators did not address the effect of the BVS on thrombotic risk.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EIn a patient population with minimal exclusion criteria and using LLL as an early and robust marker for restenosis, the BVS demonstrated satisfactory angiographic and clinical outcomes compared with the EES\/BES. In-segment LLL was slightly but significantly higher with the BVS compared with the EES\/BES. A possible explanation for this difference may be the modest and transient constrictive effect at the scaffold edges [Gogas B et al. \u003Cem\u003EJACC Cardiovasc Interv\u003C\/em\u003E. 2012]. These results reinforce the authors\u0027 primary hypothesis of DES superiority within 6 to 12 months. The optimal DAPT duration after BVS implantation is not known.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/30\/20.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzotfp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}