Summary

Patients with obesity, insulin resistance, and T2DM have postprandial hyperglycemia and impaired postprandial microvascular response. This article reviews results from the Effects of PDE-5 Inhibition on Postprandial Hyperglycemia in Type 2 Diabetes study [NCT01238224], which investigated the effect of tadalafil on postprandial hyperglycemia and circulating levels of proinflammatory markers in patients with T2DM after a mixed meal.