Genetics Can Unravel the Pathogenesis of Diabetes

Article Figures & Data

Figures

  • Figure 1.

    GKRP-P446L Protein Has Reduced Ability to Inhibit Liver Glucokinase

    Sources: Rees SD et al. Diabetologia. 2011; Beer NL et al. Hum Mol Genet. 2009.
  • Figure 2.

    PTEN Mutation Causes a Decrease in Insulin Release Following an Oral Glucose Tolerance Test

    PTEN, phosphatase and tensin homolog. PTEN mutation present in patient group.From New England Journal of Medicine, Pal A et al. PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity. 2012;367:1002–1011. Copyright © 2012 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
  • Figure 3.

    Obesity Higher in Patients With PTEN Mutation

    BMI, body mass index; PTEN, phosphatase and tensin homolog.From New England Journal of Medicine, Pal A et al. PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity. 2012;367:1002–1011. Copyright © 2012 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
  • The editors would like to thank the many members of the European Association for the Study of Diabetes 2014 presenting faculty who generously gave their time to ensure the accuracy and quality of the articles in this publication.