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GKRP-P446L Protein Has Reduced Ability to Inhibit Liver Glucokinase
Sources: Rees SD et al. Diabetologia. 2011; Beer NL et al. Hum Mol Genet. 2009.
PTEN Mutation Causes a Decrease in Insulin Release Following an Oral Glucose Tolerance Test
PTEN, phosphatase and tensin homolog.
PTEN mutation present in patient group.
From New England Journal of Medicine, Pal A et al. PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity. 2012;367:1002–1011. Copyright © 2012 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
Obesity Higher in Patients With PTEN Mutation
BMI, body mass index; PTEN, phosphatase and tensin homolog.
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