RT Journal Article SR Electronic A1 Vinall, Phil T1 Systemic Treatment for Advanced NSCLC JF MD Conference Express YR 2014 FD SAGE Publications VO 14 IS 36 SP 29 OP 30 DO 10.1177/155989771436022 UL http://mdc.sagepub.com/content/14/36/29.abstract AB The recent understanding of the relation between the cancer cell and the immune system includes a knowledge of how the cancer cell produces proteins that prevent the immune system from recognizing and killing the cancer cell, as well as the identification of a series of inhibitory receptors, activating receptors, and other pathways. This understanding is advancing the field of systemic immune therapy for oncology. Non-small cell lung cancer (NSCLC) is a heterogeneous disease with numerous driver mutations. This article discusses new insights into immune privilege, improved diagnosis, as well as the need for drugs to overcome secondary resistance to systemic treatment.