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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EModerate to severe plaque psoriasis has both physical and psychological effects, leading to major impairment of health-related quality of life. Tofacitinib, an oral Janus kinase inhibitor, was found to be effective in A Phase 3, Multi Site, Randomized, Double Blind, Placebo Controlled Study of the Efficacy and Safety Comparing CP- 690,550 and Etanercept in Subjects With Moderate to Severe Chronic Plaque Psoriasis [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01241591\u0026amp;atom=%2Fspmdc%2F14%2F37%2F9.atom\u0022\u003ENCT01241591\u003C\/a\u003E]. The objective of this analysis of the tofacitinib phase 3 trial was to assess the effects of tofacitinib (5 and 10 mg, BID) versus etanercept or placebo on patient-reported outcomes.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ESkin Diseases\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ESkin Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDermatology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EModerate to severe plaque psoriasis has both physical [Strand V et al. \u003Cem\u003EAnn Rheum Dis.\u003C\/em\u003E 2012; Reich A et al. \u003Cem\u003EActa Derm Venereol\u003C\/em\u003E. 2010] and psychological effects [Kurd SK et al. \u003Cem\u003EArch Dermatol\u003C\/em\u003E. 2010; Kimball AB et al. \u003Cem\u003EAm J Clin Dermatol\u003C\/em\u003E. 2005], leading to major impairment of health-related quality of life (QOL). Tofacitinib, an oral Janus kinase inhibitor, was found to be effective in A Phase 3, Multi Site, Randomized, Double Blind, Placebo Controlled Study of the Efficacy and Safety Comparing CP-690,550 and Etanercept in Subjects With Moderate to Severe Chronic Plaque Psoriasis [\u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT01241591\u0026amp;atom=%2Fspmdc%2F14%2F37%2F9.atom\u0022\u003ENCT01241591\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe objective of this analysis of the tofacitinib phase 3 trial, presented by Fernando Valenzuela, MD, University of Chile Clinical Hospital, Santiago, Chile, was to assess the effects of tofacitinib (5 and 10 mg, BID) versus etanercept or placebo on patient-reported outcomes. After a 4-week screening period, patients with psoriasis for \u2265 12 months were randomized 3:3:3:1 to tofacitinib, 5 mg (n = 330) or 10 mg (n = 332) BID, plus subcutaneous (SC) placebo twice weekly; etanercept, 50 mg, SC, twice weekly plus placebo BID (n = 336); or placebo BID plus SC placebo twice weekly (n = 108). The patients were stratified by the number of failed prior systemic therapies.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe main inclusion criteria were as follows: Psoriasis Area Severity Index \u2265 12; Physician\u0027s Global Assessment of moderate or severe psoriasis; psoriasis on \u2265 10% of the body surface area; and failed, intolerant, or contraindication to \u2265 1 systemic therapy (\u2265 2 in some countries). Patients with nonplaque or drug-induced psoriasis or evidence of active infection were excluded. The patient-reported outcome end points assessed at week 12 were as follows: Dermatology Life Quality Index (DLQI), Itch Severity Item (ISI), Patient Global Assessment (PtGA), and Patient Satisfaction With Study Medication (PSSM).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EBaseline patient demographics and disease characteristics were well balanced across the treatment groups. The mean baseline scores on several end points (including the DLQI, ISI, and PtGA) indicated a substantial disease burden on QOL in this patient population. The patients in both tofacitinib dosage groups experienced a rapid, significant improvement in itch severity as early as day 2 (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .05; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E). From week 2, among patients with a baseline ISI \u0026gt; 1, all active treatment groups had a significantly greater percentage of patients with ISI \u2264 1 (little to no itching) vs placebo (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Itch Severity Item Score Showed Rapid Improvement With Tofacitinib\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-683378854\u0022 data-figure-caption=\u0022Itch Severity Item Score Showed Rapid Improvement With Tofacitinib\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12130\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EItch Severity Item Score Showed Rapid Improvement With Tofacitinib\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EBIW, twice weekly; ISI, Itch Severity Item; LS, least squares; SC, subcutaneous; SE, Standard error.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003E\n            \u003Csup\u003Ea\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.05 vs placebo; \u003Csup\u003Eb\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.0001 vs placebo; \u003Csup\u003Ec\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.05 vs etanercept; \u003Csup\u003Ed\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.001 vs etanercept; \u003Csup\u003Ee\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.0001 vs etanercept.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003EReproduced with permission from F Valenzuela, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EAt weeks 4 and 12, the mean DLQI score demonstrated significant improvement from baseline with tofacitinib (5 and 10 mg) and etanercept (50 mg) vs placebo (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001 for all vs placebo at weeks 4 and 12; \u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003EFigure 2\u003C\/a\u003E). Among patients with baseline DLQI \u0026gt; 1, significantly more patients receiving active treatment reported DLQI \u2264 1 (no effect of psoriasis on QOL) vs placebo (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001).\u003C\/p\u003E\u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Dermatology Life Quality Index Score Improved With Tofacitinib\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-683378854\u0022 data-figure-caption=\u0022Dermatology Life Quality Index Score Improved With Tofacitinib\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 2.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F2.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/37\/9\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/12131\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2.\u003C\/span\u003E \n            \u003Cp id=\u0022p-8\u0022 class=\u0022first-child\u0022\u003EDermatology Life Quality Index Score Improved With Tofacitinib\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-4\u0022\u003EBIW, twice weekly; DLQI, Dermatology Life Quality Index; LS, least squares; SC, subcutaneous; SE, standard error.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-5\u0022\u003E\n            \u003Csup\u003Ea\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.05 vs placebo; \u003Csup\u003Eb\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.0001 vs placebo; \u003Csup\u003Ec\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.05 vs etanercept; \u003Csup\u003Ed\u003C\/sup\u003E\n            \u003Cem\u003EP\u003C\/em\u003E \u0026lt;.001 vs etanercept.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-6\u0022\u003EReproduced with permission from F Valenzuela, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-9\u0022\u003EFrom week 4, significantly more patients receiving active treatment reported a PtGA of \u201cclear\u201d or \u201calmost clear\u201d versus those receiving placebo (\u003Cem\u003EP\u003C\/em\u003E \u0026lt; .0001). More than 50% of patients receiving tofacitinib (10 mg) or etanercept achieved a PtGA of \u201cclear\u201d or \u201calmost clear.\u201d More than 70% of patients receiving active treatment were satisfied with their treatment at week 12, as assessed by the PSSM.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EThe results of this study demonstrated that patients treated with tofacitinib (5 or 10 mg, BID) exhibited significant improvement across multiple measures of health-related QOL when compared with placebo. These results suggest that oral tofacitinib may be an effective new treatment option for patients with moderate to severe chronic plaque psoriasis.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/37\/9.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzookp\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzookp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}