RT Journal Article
SR Electronic
A1 Buckley, Rita
T1 BK Channel Blocker Rapidly Reverses OIRD
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 40
SP 13
OP 14
DO 10.1177/155989771440007
UL http://mdc.sagepub.com/content/14/40/13.2.abstract
AB A pharmacokinetic/pharmacodynamic (PK/PD) modeling study on the effect of the BK channel blocker GAL021 found that it produced rapid reversal of opioid-induced respiratory depression (OIRD) in a population of healthy male volunteers. This article discusses a study assessing whether GAL21 stimulates breathing in OIRD and evaluated its safety in a proof-of-concept, double-blind crossover study on isohypercapnic ventilation and a subsequent double-blind exploratory study on poikilocapnic ventilation and nonrespiratory end points.