Summary

Chronic hepatitis B virus (HBV) infection is rarely cured with current therapies, and there is no effective therapy for hepatitis D virus (HBD) coinfection. Myrcludex B is a first-in-class entry inhibitor that inactivates the HBV and HDV receptor sodium taurocholate cotransporting polypeptide. This article discusses a phase 2a study evaluating the safety, tolerability, and antiviral efficacy of Myrcludex B.