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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EThis article discusses the main results of the randomized BASKET Prospective Validation Examination II trial [BASKET-PROVE II], which compared the long-term outcome of biodegradable-polymer drug-eluting stents to both durable-polymer drug-eluting stents and bare metal stents.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EBASKET-PROVE\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecardiology clinical trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Einterventional techniques \u0026amp; devices\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EChristoph A. Kaiser, MD, University Hospital Basel, Basel, Switzerland, discussed the main results of the randomized BASKET Prospective Validation Examination II trial [BASKET-PROVE II; Kaiser C et al. \u003Cem\u003ECirculation.\u003C\/em\u003E 2014], which compared the long-term outcome of biodegradable-polymer drug-eluting stents (BP-DEs) to both durable-polymer drug-eluting stents (DP-DESs) and bare metal stents (BMSs).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EIn BASKET-PROVE II, 2291 patients requiring \u2265 3.0-mm stents were randomized between April 2010 to May 2012 in a 1:1:1 fashion to either a biolimus-eluting BP-DES (Nobori; n = 765), an everolimus-eluting DP-DES (Xience-PRIME; n =765), or a thin-strut coated cobalt-chromium BMS (Prokinetik; n = 761). Patients with shock, in-stent restenosis, stent thrombosis (ST), unprotected left main or saphenous vein graft, planned surgery within 12 months, increased bleeding risk due to oral anticoagulant, and history of stroke or transient ischemic attack and who required stents \u0026gt; 4 mm in diameter were excluded.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe noninferiority margin for the BP-DES versus DP-DES comparison was 3.8%, based on prior findings [Kaiser C et al. \u003Cem\u003EN Engl J Med.\u003C\/em\u003E 2010]. The primary efficacy end point during the 2-year follow-up after stent implantation was the occurrence of major adverse cardiac events (defined as cardiovascular [CV] death, myocardial infarction [MI], or target vessel revascularization). A superiority analysis was planned between the BP-DES and BMS using a secondary safety end point of CV death, MI, or definite\/probable ST.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EBaseline characteristics were comparable in the 3 trial arms. At 2-year follow-up, 98.5% of patients were alive and 97.7% of patients remained in follow-up. The primary end point was comparable in patients receiving BP-DES and those receiving DP-DES (2-year rate, 7.6% vs 6.8%; absolute risk difference, 0.75%; 95% CI, \u22121.93% to 3.50%; \u003Cem\u003EP\u003C\/em\u003E\n            \u003Csub\u003ENoninferiority\u003C\/sub\u003E = .04; HR, 1.11; 95% CI, 0.77 to 1.62; \u003Cem\u003EP\u003C\/em\u003E = .58; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Primary End Point Between Drug-Eluting Stents\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-2124194497\u0022 data-figure-caption=\u0022Primary End Point Between Drug-Eluting Stents\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15202\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EPrimary End Point Between Drug-Eluting Stents\u003C\/p\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EBMS, bare metal stent; BP-DES, biodegradable-polymer drug-eluting stent; DP-DES, durable-polymer drug-eluting stent.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-2\u0022\u003EAdapted from Kaiser C et al. Long-Term Efficacy and Safety of Biodegradable-Polymer Biolimus-Eluting Stents Main Results of the Basel Stent Kosten-Effektivit\u00e4ts Trial-PROspective Validation Examination II (BASKET-PROVE II), A Randomized, Controlled Noninferiority 2-Year Outcome Trial. \u003Cem\u003ECirculation.\u003C\/em\u003E E-pub ahead of print. DOI: 10.1161\/CIRCULATIONAHA.114.013520. Accessed December 10, 2014. With permission from American Heart Association, Inc.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-7\u0022\u003EThe results were consistent in the per-protocol population although it did not meet the prespecified noninferiority margin (absolute risk difference, 1.41%; 95% CI, 1.33% to 4.15%; \u003Cem\u003EP\u003C\/em\u003E\n            \u003Csub\u003ENoninferiority\u003C\/sub\u003E = .09). Both DES platforms had lower occurrence of target vessel revascularization as compared with BMS.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EThe secondary safety end point was similar for BP-DES as compared with BMS (3.7% vs 5.0%; HR, 0.72; 95% CI, 0.44 to 1.18; \u003Cem\u003EP\u003C\/em\u003E = .20; left panel of \u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003EFigure 2\u003C\/a\u003E). A landmark analysis at 1 year revealed no difference in late safety between the 2 stents (right panel of \u003Ca id=\u0022xref-fig-2-2\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003EFigure 2\u003C\/a\u003E).\u003C\/p\u003E\u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Key Safety Secondary End Point Between BP-DES and BMS\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-2124194497\u0022 data-figure-caption=\u0022Key Safety Secondary End Point Between BP-DES and BMS\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 2.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F2.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/14\/52\/20\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/15203\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2.\u003C\/span\u003E \u003Cp id=\u0022p-9\u0022 class=\u0022first-child\u0022\u003EKey Safety Secondary End Point Between BP-DES and BMS\u003C\/p\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-3\u0022\u003EBMS, bare metal stent; BP-DES, biodegradable-polymer drug-eluting stent; DP-DES, durable-polymer drug-eluting stent.\u003C\/q\u003E\u003Cq class=\u0022attrib\u0022 id=\u0022attrib-4\u0022\u003EAdapted from Kaiser C et al. Long-Term Efficacy and Safety of Biodegradable-Polymer Biolimus-Eluting Stents Main Results of the Basel Stent Kosten-Effektivit\u00e4ts Trial- PROspective Validation Examination II (BASKET-PROVE II), A Randomized, Controlled Noninferiority 2-Year Outcome Trial. \u003Cem\u003ECirculation.\u003C\/em\u003E E-pub ahead of print. DOI: 10.1161\/CIRCULATIONAHA.114.013520. Accessed December 10, 2014. With permission from American Heart Association, Inc.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-10\u0022\u003EIn summary, BP-DES were noninferior to DP-DES after 2 years in patients requiring large-vessel stents. Both were superior to BMS in efficacy. There was no evidence of superior safety of BP-DES beyond 1 year. The findings do not support the idea that polymers are key in the perceived association of DP-DES with very late ST, although the trial was not powered to definitively assess this.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/14\/52\/20.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzod01\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzod01\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}