RT Journal Article
SR Electronic
A1 Hitt Nichols, Emma
T1 PCC Reverses Dabigatran-Associated Bleeding in Polytrauma Model
JF MD Conference Express
YR 2014
FD SAGE Publications
VO 14
IS 55
SP 22
OP 22
DO 10.1177/1559897715570604
UL http://mdc.sagepub.com/content/14/55/22.abstract
AB In a porcine polytrauma model with dabigatran-associated bleeding, bleeding rates were reduced and 100% survival rates were achieved by infusion with 4-factor prothrombin complex concentrate. The effect of 4-factor prothrombin complex concentrate was further enhanced by the addition of tranexamic acid and fibrinogen. However, tranexamic acid and fibrinogen alone did not reduce blood loss or improve survival rates compared with placebo.