PT  - JOURNAL ARTICLE
AU  - Hitt Nichols, Emma
ED  - Grottke, Oliver
TI  - PCC Reverses Dabigatran-Associated Bleeding in Polytrauma Model
DP  - 2014  01
TA  - MD Conference Express
PG  - 22--22
VI  - 14
IP  - 55
4099  - http://mdc.sagepub.com/content/14/55/22.short
4100  - http://mdc.sagepub.com/content/14/55/22.full
AB  - In a porcine polytrauma model with dabigatran-associated bleeding, bleeding rates were reduced and 100% survival rates were achieved by infusion with 4-factor prothrombin complex concentrate. The effect of 4-factor prothrombin complex concentrate was further enhanced by the addition of tranexamic acid and fibrinogen. However, tranexamic acid and fibrinogen alone did not reduce blood loss or improve survival rates compared with placebo.