Summary
Apixaban anticoagulation was rapidly reversed by 4 factor–prothrombin complex concentrate in healthy volunteers, as measured by endogenous thrombin potential. Adverse events occurred more frequently after 4 factor–prothrombin complex concentrate compared with placebo, most commonly nasopharyngitis and abdominal pain. However, there were no reports of thrombosis or other serious adverse events.
- 4 factor–prothrombin complex concentrate
- reversal
- anticoagulant
- endogenous thrombin potential
- apixaban
- 4F-PCC
- Reversibility of Apixaban Anticoagulation With the Four Factor Prothrombin Complex Concentrate Kcentra
- 4PAR
- NCT02270918
- © 2014 SAGE Publications