Summary
This study identifies a potential mechanism of action for lenalidomide in del(5q) myelodysplastic syndrome and identifies a single nonconserved amino acid in mice and humans that determines lenalidomide susceptibility. The results may facilitate the development of improved preclinical models and reinforces the importance of haploinsufficient genes in the pathogenesis and treatment of disease.
- del(5q)
- mouse model
- human cell lines
- proteomics
- ubiquitination
- degradation
- lenalidomide
- © 2014 SAGE Publications
Tools
Table of contents
Cited By...
- No citing articles found.