Summary

New research findings can now explain the complete pathway for the regulation of thrombopoietin production, which regulates the production of platelets. Platelets lacking sialic acid due to aging are removed by the Ashwell-Morell receptor. The signaling pathways Janus kinase 2 and signal transducer and activator of transcription 3 then stimulates the production of thrombopoietin within the hepatocyte nucleus.