PT  - JOURNAL ARTICLE
AU  - Kuznar, Wayne
ED  - Turner, Nicholas
ED  - Tutt, Andrew
ED  - Winer, Eric P.
TI  - Heterogeneity, Genome Complexity of TNBC Complicate Therapy
DP  - 2014  01
TA  - MD Conference Express
PG  - 23--24
VI  - 14
IP  - 56
4099  - http://mdc.sagepub.com/content/14/56/23.short
4100  - http://mdc.sagepub.com/content/14/56/23.full
AB  - Triple-negative breast cancer is a heterogeneous disease and therefore presents treatment challenges, as targetable characteristic molecular abnormalities have not yet been identified. As with BRCA1-associated breast cancer, defective DNA repair and homologous recombination are implicated in sporadic TNBC, engendering sensitivity to platinum chemotherapy and poly (ADP-ribose) polymerase.