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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-1\u0022\u003EDear Colleagues,\u003C\/p\u003E\n         \u003Cp id=\u0022p-2\u0022\u003EWe are pleased to share the peer-reviewed highlights of the 2014 San Antonio Breast Cancer Symposium, held in San Antonio, Texas, from December 9 to 13, 2014.\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003E\n            \u003Cem\u003EMD Conference Express\u003C\/em\u003E\n            \u003Csup\u003E\u00ae\u003C\/sup\u003E provides timely, peer-reviewed highlights of high-impact presentations from the live conference, long before they are published in the academic literature, and is a trusted education resource. The articles selected for this issue underwent a rigorous 5-step peer-review process to ensure their accuracy and provide a reliable interim information source prior to the research being vetted by the standard journal peer-review process.\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe articles in this issue of \u003Cem\u003EMD Conference Express\u003C\/em\u003E represent the most compelling topics of relevance to a broad array of practitioners and have the potential to influence clinical practice.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EAmong the clinical trial highlights presented at the meeting, the phase III SOFT trial demonstrated there was no overall benefit for the addition of ovarian suppression to tamoxifen compared to tamoxifen alone in premenopausal women with hormone-receptor-positive breast cancer. However, in the cohort of women who remained premenopausal after chemotherapy, there was a significant improvement with the addition of ovarian suppression to tamoxifen, a practice-changing result. The BOLERO-1 study found that progression-free survival was not improved by adding everolimus to weekly trastuzumab and paclitaxel first-line treatment of HER2-positive advanced breast cancer. The TNT trial showed that outcomes were similar with carboplatin and docetaxel in women with advanced triple-negative breast cancer (TNBC). However, in women with BRCA1\/2 gene mutations, carboplatin improved outcomes, including the objective response rate and PFS.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EThe feature articles summarize lectures on pharmacogenomics, including genome-wide association and functional genomic studies, and molecular profiling, which have provided insights into the new biology of breast cancer and identified mutations in estrogen receptor (ER)-positive breast cancer that are targets for genome-directed therapeutics.\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EThe selected update articles provide reviews of the genomic complexity and heterogeneity of TNBC that are hindering the development of effective treatment strategies, and current perspectives on neoadjuvant therapy for ER-positive breast cancer, including novel targeted agents. Rounding out this edition are articles on evidence-based adjuvant endocrine therapy and the identification of the drivers of metastatic breast cancer.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EWe hope that you find the articles and practical perspectives that are contained in the pages of this issue of \u003Cem\u003EMD Conference Express\u003C\/em\u003E helpful in integrating this new information into your clinical practice. For more information, please visit \u003Ca href=\u0022http:\/\/www.mdconferencexpress.com\u0022\u003Ewww.mdconferencexpress.com\u003C\/a\u003E.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cdiv class=\u0022sig-block\u0022\u003E\n         \u003Cdiv class=\u0022sig\u0022\u003E\u003Cp\u003E\n            \u003Cstrong\u003ESara Tolaney, MD, MPH\u003C\/strong\u003E\n            \u003Cbr\/\u003EDana-Farber Cancer Institute\u003Cbr\/\u003EHarvard Medical School\u003Cbr\/\u003EBoston, MA, USA\u003C\/p\u003E\u003C\/div\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2014 SAGE Publications\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzo77q\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}