PT - JOURNAL ARTICLE AU - Nichols, Emma Hitt ED - Albain, Kathy S. TI - Treatment on the Edges: Discordance between Stage and Biology DP - 2013 Mar 01 TA - MD Conference Express PG - 4--5 VI - 12 IP - 20 4099 - http://mdc.sagepub.com/content/12/20/4.short 4100 - http://mdc.sagepub.com/content/12/20/4.full AB - One of the more difficult issues that clinicians face when helping patients make adjuvant therapy decisions is what to do when discordance exists between two important predictors of relapse risk: tumor stage and tumor biology [Albain KS. SABCS 2012 (abstr CS1–1)]. Patients with higher-stage tumors (ie, large tumors, multiple positive lymph nodes) of favorable biology (eg, luminal A tumors) and those with the opposite situation (ie, small tumors with aggressive biology) can render adjuvant therapy choices difficult.