RT Journal Article SR Electronic A1 Vinall, Maria T1 OPTiM Study Results JF MD Conference Express YR 2013 FD SAGE Publications VO 13 IS 6 SP 17 OP 17 DO 10.1177/155989771306011 UL http://mdc.sagepub.com/content/13/6/17.1.abstract AB Results from the Efficacy and Safety Study of OncoVEX Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Compared to GM-CSF in Melanoma [OPTiM; NCT00769704; Andtbacka RHI et al. J Clin Oncol 2013 (suppl; abstr LBA9008)] showed that a genetically modified version of herpes simplex virus type 1 (talimogene laherparepvec), is safe and improves durable response rate in patients with unresectable stage IIIB-IV melanoma.