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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EIn patient-reported outcomes for those with recently diagnosed rheumatoid arthritis,\n               treatment with etanercept 25 mg plus methotrexate (MTX) was superior to MTX plus\n               placebo or placebo alone in maintenance of remission and therapeutic effect. This\n               article discusses a poster of the results of A 3-Phase Study to Evaluate Sustained\n               Remission and Productivity Outcomes in Subjects With Early Rheumatoid Arthritis\n               Initiated on Treatment With Etanercept Plus Methotrexate [PRIZE;\n               EUCTR2008-00263-85-IT; Emery P et al. EULAR 2013 (poster 0543)].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatoid Arthritis\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatoid Arthritis\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\n         \n         \u003Cp id=\u0022p-2\u0022\u003EIn patient-reported outcomes for those with recently diagnosed rheumatoid arthritis\n            (RA), treatment with etanercept 25 mg (ETN25) plus methotrexate (MTX) was superior to\n            MTX plus placebo or placebo alone in maintenance of remission and therapeutic effect.\n            Paul Emery, MD, University of Leeds, Leeds, United Kingdom, presented a poster of the\n            results of A 3-Phase Study to Evaluate Sustained Remission and Productivity Outcomes in\n            Subjects With Early Rheumatoid Arthritis Initiated on Treatment With Etanercept Plus\n            Methotrexate [PRIZE; EUCTR2008-00263-85-IT; Emery P et al. EULAR 2013 (poster\n            0543)].\u003C\/p\u003E\n         \u003Cp id=\u0022p-3\u0022\u003EThe open-label, double-blind, 39-week Phase 2 study evaluated patients who had achieved\n            remission by Week 52 in Phase 1 (28-joint disease activity score [DAS28] \u22643.2 at Week 39\n            and DAS28 \u0026lt;2.6 at Week 52), during which moderate to severe RA patients diagnosed\n            within \u22641 year without previous MTX or biologic treatment were treated with ETN 50 mg\n            plus MTX. Phase 2 patients were randomized 1:1:1 to ETN25 plus MTX (n=63), MTX plus\n            placebo injection (n=65), or placebo capsules plus placebo injection at Week 52 (n=65).\n            Patient-reportd outcomes in RA have shown significant improvement through treatment with\n            biologic drugs [Bala S-V et al. \u003Cem\u003EMusculoskeletal Care\u003C\/em\u003E 2010].\u003C\/p\u003E\n         \u003Cp id=\u0022p-4\u0022\u003EThe patients entering Phase 2 were a mean 49.4 years and 64.8% were women. The mean\n            disease duration was 6.8 months and the mean diagnosis duration was 2.3 months. Almost\n            41% had taken corticosteroids, 17.1% had taken disease-modifying antirheumatic drugs,\n            and 66.3% had taken nonsteroidal anti-inflammatory drugs.\u003C\/p\u003E\n         \u003Cp id=\u0022p-5\u0022\u003EOf 193 patients entering Phase 2, 144 completed the trial, including 132 responders\n            (ETN25+MTX=56; MTX=50; placebo=38), and 12 nonresponders (ETN25+MTX=3; MTX=4;\n            placebo=35). For the noncompleters, three adverse events occurred in the ETN\/MTX group\n            and one occurred in the placebo group. Of the 28 noncompleters in the unsatisfactory\n            response category, 17 were in the placebo group, 11 were in the MTX group, but none was\n            in the ETN\/MTX group. No significant radiographic disease progression was reported in\n            any treatment group.\u003C\/p\u003E\n         \u003Cp id=\u0022p-6\u0022\u003EETN\/MTX patients reported significantly greater benefits in maintenance of health,\n            quality of life (QoL), levels of fatigue, and activity impairment compared with placebo\n            patients (p\u0026lt;0.0001), and maintenance of effect was significantly greater at the last\n            observation carried forward for ETN\/MTX patients compared with placebo patients. The\n            ETN\/MTX group also reported significantly greater low risk of work instability than the\n            placebo group (p=0.0011).\u003C\/p\u003E\n         \u003Cp id=\u0022p-7\u0022\u003EPhase 2 patients reported several clinically meaningful improvements, including scoring\n            0 to 3 (clinically meaningful \u0394 \u22650.22) on the Health Assessment Questionnaire-Disability\n            Index (HAQ-DI), scoring 0 to 52 (clinically meaningful \u0394 \u22653.0) on the Functional\n            Assessment of Chronic Illness Therapy (FACIT-Fatigue) test, and scoring 0 to 1\n            (clinically meaningful \u0394 \u22650.05) for QoL on the EuroQoL-5 Dimensions (EQ-5D) utility\n            score.\u003C\/p\u003E\n         \u003Cp id=\u0022p-8\u0022\u003EPRIZE Phase 2 patients report clinically relevant improvements in quality of life based\n            on EQ-5D utility scores.\u003C\/p\u003E\n         \u003Cp id=\u0022p-9\u0022\u003EOf the responders, 131 entered Phase 3, during which the ETN\/MTX dose was tapered for 2\n            to 4 weeks and the patients are to be observed for the remainder of the 121-week PRIZE\n            trial.\u003C\/p\u003E\n         \u003Cp id=\u0022p-10\u0022\u003EPRIZE Phase 2 patients reported clinically relevant health improvements based on HAQ-DI\n            scores.\u003C\/p\u003E\n      \u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/8\/14.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznsg1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}