RT Journal Article
SR Electronic
A1 Cunningham, Muriel
T1 Insulin Dose Not Linked to Cardiovascular Mortality in the ACCORD Trial
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 11
SP 12
OP 13
DO 10.1177/155989771311008
UL http://mdc.sagepub.com/content/13/11/12.abstract
AB Previously published results from the Action to Control Cardiovascular Risk in Diabetes study [ACCORD; ACCORD Study Group. N Engl J Med 2008] showed an increased risk of all-cause and cardiovascular (CV) mortality in the intensive control group (HbA1C target, <6.0%) compared with the less intensive group (HbA1C target, 7.0% to 7.9%). Several post hoc analyses did not find a conclusive link between the ACCORD results and factors such as hypoglycemia, low HbA1C, the rapid decline in HbA1C during the first year of the study, weight gain, and specific medication use.